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Mutant p53 tunes the NRF2-dependent antioxidant response to support survival of cancer cells
NRF2 (NFE2L2) is one of the main regulators of the antioxidant response of the cell. Here we show that in cancer cells NRF2 targets are selectively upregulated or repressed through a mutant p53-dependent mechanism. Mechanistically, mutant p53 interacts with NRF2, increases its nuclear presence and r...
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| Pubblicato in: | Oncotarget |
|---|---|
| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Impact Journals LLC
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5945496/ https://ncbi.nlm.nih.gov/pubmed/29755668 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.24974 |
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