A Preclinical Population Pharmacokinetic Model for Anti‐CD20/CD3 T‐Cell‐Dependent Bispecific Antibodies

CD20 is a cell‐surface receptor expressed by healthy and neoplastic B cells and is a well‐established target for biologics used to treat B‐cell malignancies. Pharmacokinetic (PK) and pharmacodynamic (PD) data for the anti‐CD20/CD3 T‐cell‐dependent bispecific antibody BTCT4465A were collected in tran...

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Bibliographic Details
Published in:Clin Transl Sci
Main Authors: Ferl, Gregory Z., Reyes, Arthur, Sun, Liping L., Cheu, Melissa, Oldendorp, Amy, Ramanujan, Saroja, Stefanich, Eric G.
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2018
Subjects:
Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5944627/
https://ncbi.nlm.nih.gov/pubmed/29351372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cts.12535
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