NLRP3 Inflammasome and Caspase-1/11 Pathway Orchestrate Different Outcomes in the Host Protection Against Trypanosoma cruzi Acute Infection

Infection with protozoan parasite Trypanosoma cruzi results in activation of nucleotide-binding domain and leucine-rich repeat containing receptors (NLRs). NLR activation leads to inflammasome formation, the activation of caspase-1, and the subsequent cleavage of IL-1β and IL-18. Considering that in...

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Dades bibliogràfiques
Publicat a:Front Immunol
Autors principals: Paroli, Augusto F., Gonzalez, Patricia V., Díaz-Luján, Cintia, Onofrio, Luisina I., Arocena, Alfredo, Cano, Roxana C., Carrera-Silva, Eugenio A., Gea, Susana
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2018
Matèries:
Immunology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5944318/
https://ncbi.nlm.nih.gov/pubmed/29774028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.00913
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