Determination of Tobramycin in M(9) Medium by LC-MS/MS: Signal Enhancement by Trichloroacetic Acid

It is well known that ion-pairing reagents cause ion suppression in LC-MS/MS methods. Here, we report that trichloroacetic acid increases the MS signal of tobramycin. To support studies of an in vitro pharmacokinetic/pharmacodynamic simulator for bacterial biofilms, an LC-MS/MS method for determinat...

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Bibliographic Details
Published in:J Anal Methods Chem
Main Authors: Huang, Liusheng, Haagensen, Janus Anders Juul, Verotta, Davide, Cheah, Vincent, Spormann, Alfred M., Aweeka, Francesca, Yang, Katherine
Format: Artigo
Language:Inglês
Published: Hindawi 2018
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5944200/
https://ncbi.nlm.nih.gov/pubmed/29854560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2018/7965124
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