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Determination of Tobramycin in M9 Medium by LC-MS/MS: Signal Enhancement by Trichloroacetic Acid

It is well known that ion-pairing reagents cause ion suppression in LC-MS/MS methods. Here, we report that trichloroacetic acid increases the MS signal of tobramycin. To support studies of an in vitro pharmacokinetic/pharmacodynamic simulator for bacterial biofilms, an LC-MS/MS method for determinat...

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Detalhes bibliográficos
Main Authors: Liusheng Huang, Janus Anders Juul Haagensen, Davide Verotta, Vincent Cheah, Alfred M. Spormann, Francesca Aweeka, Katherine Yang
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Limited 2018-01-01
Colecção:Journal of Analytical Methods in Chemistry
Acesso em linha:http://dx.doi.org/10.1155/2018/7965124
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