Flavopiridol Protects Bone Tissue by Attenuating RANKL Induced Osteoclast Formation

Bone resorption and homeostasis is carried out by osteoclasts, whose differentiation and activity are regulated by the RANK/RANKL axis. Our previous studies using a mouse model of joint injury show that joint trauma induces local inflammation followed by bone remodeling. The transcription factor cyc...

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Publicat a:Front Pharmacol
Autors principals: Hu, Zi’ang, Chen, Yilei, Song, Lijiang, Yik, Jasper H. N., Haudenschild, Dominik R., Fan, Shunwu
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2018
Matèries:
Pharmacology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5944179/
https://ncbi.nlm.nih.gov/pubmed/29773986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.00174
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