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Methylglyoxal Disrupts Paranodal Axoglial Junctions via Calpain Activation

Nodes of Ranvier and associated paranodal and juxtaparanodal domains along myelinated axons are essential for normal function of the peripheral and central nervous systems. Disruption of these domains as well as increases in the reactive carbonyl species methylglyoxal are implicated as a pathophysio...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:ASN Neuro
Hauptverfasser: Griggs, Ryan B., Yermakov, Leonid M., Drouet, Domenica E., Nguyen, Duc V.M., Susuki, Keiichiro
Format: Artigo
Sprache:Inglês
Veröffentlicht: SAGE Publications 2018
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5944142/
https://ncbi.nlm.nih.gov/pubmed/29673258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1759091418766175
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