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Methylglyoxal Disrupts Paranodal Axoglial Junctions via Calpain Activation

Nodes of Ranvier and associated paranodal and juxtaparanodal domains along myelinated axons are essential for normal function of the peripheral and central nervous systems. Disruption of these domains as well as increases in the reactive carbonyl species methylglyoxal are implicated as a pathophysio...

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Detalhes bibliográficos
Main Authors: Ryan B. Griggs, Leonid M. Yermakov, Domenica E. Drouet, Duc V.M. Nguyen, Keiichiro Susuki
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE Publishing 2018-04-01
Colecção:ASN Neuro
Acesso em linha:https://doi.org/10.1177/1759091418766175
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