Biosynthetic pathway for furanosteroid demethoxyviridin and identification of an unusual pregnane side-chain cleavage

Furanosteroids, represented by wortmannin, viridin, and demethoxyviridin, are a special group of fungal-derived, highly oxygenated steroids featured by an extra furan ring. They are well-known nanomolar-potency inhibitors of phosphatidylinositol 3-kinase and widely used in biological studies. Despit...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Commun
Prif Awduron: Wang, Gao-Qian, Chen, Guo-Dong, Qin, Sheng-Ying, Hu, Dan, Awakawa, Takayoshi, Li, Shao-Yang, Lv, Jian-Ming, Wang, Chuan-Xi, Yao, Xin-Sheng, Abe, Ikuro, Gao, Hao
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2018
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5943271/
https://ncbi.nlm.nih.gov/pubmed/29743477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04298-2
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