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Biosynthesis of helvolic acid and identification of an unusual C-4-demethylation process distinct from sterol biosynthesis

Fusidane-type antibiotics represented by helvolic acid, fusidic acid and cephalosporin P(1) are a class of bacteriostatic agents, which have drawn renewed attention because they have no cross-resistance to commonly used antibiotics. However, their biosynthesis is poorly understood. Here, we perform...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Nat Commun
Main Authors: Lv, Jian-Ming, Hu, Dan, Gao, Hao, Kushiro, Tetsuo, Awakawa, Takayoshi, Chen, Guo-Dong, Wang, Chuan-Xi, Abe, Ikuro, Yao, Xin-Sheng
פורמט: Artigo
שפה:Inglês
יצא לאור: Nature Publishing Group UK 2017
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC5696383/
https://ncbi.nlm.nih.gov/pubmed/29158519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01813-9
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