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Molecular basis for the plasticity of aromatic prenyltransferases in hapalindole biosynthesis

Aromatic prenyltransferases (PTases) are enzymes that catalyze Friedel–Crafts reactions between aromatic compounds and isoprenoid diphosphates. In hapalindole biosynthesis, the aromatic PTases AmbP1 and AmbP3 exhibit surprisingly plastic selectivities. AmbP1 not only transfers the geranyl group on t...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Beilstein J Org Chem
Prif Awduron: Awakawa, Takayoshi, Abe, Ikuro
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Beilstein-Institut 2019
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6632223/
https://ncbi.nlm.nih.gov/pubmed/31354873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3762/bjoc.15.157
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