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Molecular basis for the plasticity of aromatic prenyltransferases in hapalindole biosynthesis

Aromatic prenyltransferases (PTases) are enzymes that catalyze Friedel–Crafts reactions between aromatic compounds and isoprenoid diphosphates. In hapalindole biosynthesis, the aromatic PTases AmbP1 and AmbP3 exhibit surprisingly plastic selectivities. AmbP1 not only transfers the geranyl group on t...

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Détails bibliographiques
Publié dans:Beilstein J Org Chem
Auteurs principaux: Awakawa, Takayoshi, Abe, Ikuro
Format: Artigo
Langue:Inglês
Publié: Beilstein-Institut 2019
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6632223/
https://ncbi.nlm.nih.gov/pubmed/31354873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3762/bjoc.15.157
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