Post-exposure treatment with the oxime RS194B rapidly reactivates and reverses advanced symptoms of lethal inhaled paraoxon in macaques

Fatalities from organophosphate (OP) insecticide result from both occupational and deliberate exposure; significantly impacting human health. Like nerve agents, insecticides are neurotoxins which target and inhibit acetylcholinesterases (AChE) in central and peripheral synapses in the cholinergic ne...

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Detalhes bibliográficos
Publicado no:Toxicol Lett
Main Authors: Rosenberg, Yvonne J., Wang, Jerry, Ooms, Tara, Rajendran, Narayanan, Mao, Lingjun, Jiang, Xiaoming, Lees, Jonathan, Urban, Lori, Momper, Jeremiah D., Sepulveda, Yadira, Shyong, Yan-Jye, Taylor, Palmer
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5943181/
https://ncbi.nlm.nih.gov/pubmed/29129799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.toxlet.2017.10.025
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