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High mutation rates limit evolutionary adaptation in Escherichia coli

Mutation is fundamental to evolution, because it generates the genetic variation on which selection can act. In nature, genetic changes often increase the mutation rate in systems that range from viruses and bacteria to human tumors. Such an increase promotes the accumulation of frequent deleterious...

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Bibliografske podrobnosti
izdano v:PLoS Genet
Main Authors: Sprouffske, Kathleen, Aguilar-Rodríguez, José, Sniegowski, Paul, Wagner, Andreas
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2018
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5942850/
https://ncbi.nlm.nih.gov/pubmed/29702649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007324
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