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Structural basis for membrane anchoring and fusion regulation of the Herpes Simplex Virus fusogen gB

Viral fusogens merge viral and cell membranes during cell penetration. Their ectodomains drive fusion by undergoing large-scale refolding, but little is known about the functionally important regions located within or near the membrane. Here, we report the crystal structure of the full-length glycop...

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Détails bibliographiques
Publié dans:Nat Struct Mol Biol
Auteurs principaux: Cooper, Rebecca S., Georgieva, Elka R., Borbat, Peter P., Freed, Jack H., Heldwein, Ekaterina E.
Format: Artigo
Langue:Inglês
Publié: 2018
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5942590/
https://ncbi.nlm.nih.gov/pubmed/29728654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-018-0060-6
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