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Structural basis for membrane anchoring and fusion regulation of the Herpes Simplex Virus fusogen gB

Viral fusogens merge viral and cell membranes during cell penetration. Their ectodomains drive fusion by undergoing large-scale refolding, but little is known about the functionally important regions located within or near the membrane. Here, we report the crystal structure of the full-length glycop...

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Detalhes bibliográficos
Publicado no:Nat Struct Mol Biol
Main Authors: Cooper, Rebecca S., Georgieva, Elka R., Borbat, Peter P., Freed, Jack H., Heldwein, Ekaterina E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5942590/
https://ncbi.nlm.nih.gov/pubmed/29728654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-018-0060-6
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