Development of novel cyclic NGR peptide–daunomycin conjugates with dual targeting property

Cyclic NGR peptides as homing devices are good candidates for the development of drug conjugates for targeted tumor therapy. In our previous study we reported that the Dau=Aoa-GFLGK(c[KNGRE]-GG-)-NH(2) conjugate has a significant antitumor activity against both CD13+ HT-1080 human fibrosarcoma and C...

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Veröffentlicht in:Beilstein J Org Chem
Hauptverfasser: Tripodi, Andrea Angelo Pierluigi, Tóth, Szilárd, Enyedi, Kata Nóra, Schlosser, Gitta, Szakács, Gergely, Mező, Gábor
Format: Artigo
Sprache:Inglês
Veröffentlicht: Beilstein-Institut 2018
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5942373/
https://ncbi.nlm.nih.gov/pubmed/29765472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3762/bjoc.14.78
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