Sustained clonal hematopoiesis by HLA-lacking hematopoietic stem cells without driver mutations in aplastic anemia

Clonal hematopoiesis by hematopoietic stem progenitor cells (HSPCs) that lack an HLA class I allele (HLA(−) HSPCs) is common in patients with acquired aplastic anemia (AA); however, it remains unknown whether the cytotoxic T lymphocyte (CTL) attack that allows for survival of HLA(−) HSPCs is directe...

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Vydáno v:Blood Adv
Hlavní autoři: Imi, Tatsuya, Katagiri, Takamasa, Hosomichi, Kazuyoshi, Zaimoku, Yoshitaka, Hoang Nguyen, Viet, Nakagawa, Noriharu, Tajima, Atsushi, Yoshizato, Tetsuichi, Ogawa, Seishi, Nakao, Shinji
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2018
Témata:
Hematopoiesis and Stem Cells
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5941997/
https://ncbi.nlm.nih.gov/pubmed/29720492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2017013953
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