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TsrM as a Model for Purifying and Characterizing Cobalamin-Dependent Radical S-adenosylmethionine Methylases
Cobalamin-dependent radical S-adenosylmethionine (SAM) methylases play vital roles in the de novo biosynthesis of many antibiotics, cofactors, and other important natural products, yet remain an understudied subclass of radical SAM (RS) enzymes. In addition to a [4Fe-4S] cluster that is ligated by t...
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| Izdano u: | Methods Enzymol |
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| Glavni autori: | , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2017
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5941296/ https://ncbi.nlm.nih.gov/pubmed/28882204 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/bs.mie.2017.07.007 |
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