Targeting the mevalonate pathway is a novel therapeutic approach to inhibit oncogenic FoxM1 transcription factor in human hepatocellular carcinoma

Dysregulation of cell metabolism is a hallmark of cancer. The mevalonate pathway in lipid metabolism has been implicated as a potential target of cancer therapy for hepatocellular carcinoma (HCC). The role of the Forkhead Box M1 (FoxM1) transcription factor in HCC development has been well documente...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Ogura, Satoshi, Yoshida, Yuichi, Kurahashi, Tomohide, Egawa, Mayumi, Furuta, Kunimaro, Kiso, Shinichi, Kamada, Yoshihiro, Hikita, Hayato, Eguchi, Hidetoshi, Ogita, Hisakazu, Doki, Yuichiro, Mori, Masaki, Tatsumi, Tomohide, Takehara, Tetsuo
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2018
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5940385/
https://ncbi.nlm.nih.gov/pubmed/29765517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.24781
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