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Amide derivatives of ethacrynic acid: Synthesis and evaluation as antagonists of Wnt/β-catenin signaling and CLL cell survival
A series of amides of ethacrynic acid was prepared and evaluated for their ability to inhibit Wnt signaling and decrease the survival of CLL cells. Several of the most potent derivatives were active in the low micromolar range. Reduction of the α,β-unsaturated carbon–carbon double bond of EA abrogat...
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| Publicado en: | Bioorg Med Chem Lett |
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| Autores principales: | , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2008
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5940355/ https://ncbi.nlm.nih.gov/pubmed/19121941 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2008.12.067 |
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