Combined Hyperglycemia- and Hyperinsulinemia-Induced Insulin Resistance in Adipocytes Is Associated With Dual Signaling Defects Mediated by PKC-ζ

A hyperglycemic and hyperinsulinemic environment characteristic of type 2 diabetes causes insulin resistance. In adipocytes, defects in both insulin sensitivity and maximum response of glucose transport have been demonstrated. To investigate the molecular mechanisms, freshly isolated rat adipocytes...

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Bibliographic Details
Published in:Endocrinology
Main Authors: Lu, Huogen, Bogdanovic, Elena, Yu, Zhiwen, Cho, Charles, Liu, Lijiang, Ho, Karen, Guo, June, Yeung, Lucy S N, Lehmann, Reiner, Hundal, Harinder S, Giacca, Adria, Fantus, I George
Format: Artigo
Language:Inglês
Published: Endocrine Society 2018
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5939637/
https://ncbi.nlm.nih.gov/pubmed/29370351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2017-00312
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