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Complementary charge-based interaction between the ribosomal-stalk protein L7/12 and IF2 is the key to rapid subunit association

The interaction between the ribosomal-stalk protein L7/12 (L12) and initiation factor 2 (IF2) is essential for rapid subunit association, but the underlying mechanism is unknown. Here, we have characterized the L12–IF2 interaction on Escherichia coli ribosomes using site-directed mutagenesis, fast k...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Ge, Xueliang, Mandava, Chandra Sekhar, Lind, Christoffer, Åqvist, Johan, Sanyal, Suparna
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5939111/
https://ncbi.nlm.nih.gov/pubmed/29686090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1802001115
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