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Inhibition of translation termination by small molecules targeting ribosomal release factors

The bacterial ribosome is an important drug target for antibiotics that can inhibit different stages of protein synthesis. Among the various classes of compounds that impair translation there are, however, no known small-molecule inhibitors that specifically target ribosomal release factors (RFs). T...

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Podrobná bibliografie
Vydáno v:Sci Rep
Hlavní autoři: Ge, Xueliang, Oliveira, Ana, Hjort, Karin, Bergfors, Terese, Gutiérrez-de-Terán, Hugo, Andersson, Dan I., Sanyal, Suparna, Åqvist, Johan
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6817905/
https://ncbi.nlm.nih.gov/pubmed/31659219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-51977-1
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