Microbiota epitope similarity either dampens or enhances the immunogenicity of disease-associated antigenic epitopes

The microbiome influences adaptive immunity and molecular mimicry influences T cell reactivity. Here, we evaluated whether the sequence similarity of various antigens to the microbiota dampens or increases immunogenicity of T cell epitopes. Sets of epitopes and control sequences derived from 38 anti...

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Udgivet i:PLoS One
Main Authors: Carrasco Pro, Sebastian, Lindestam Arlehamn, Cecilia S., Dhanda, Sandeep K., Carpenter, Chelsea, Lindvall, Mikaela, Faruqi, Ali A., Santee, Clark A., Renz, Harald, Sidney, John, Peters, Bjoern, Sette, Alessandro
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5937769/
https://ncbi.nlm.nih.gov/pubmed/29734356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0196551
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