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Comparison of the effects of deferasirox, deferoxamine, and combination of deferasirox and deferoxamine on an aplastic anemia mouse model complicated with iron overload

BACKGROUND AND AIM: Iron overload is commonly observed during the course of aplastic anemia (AA), which is believed to aggravate hematopoiesis, cause multiple organ dysfunction, lead to disease progression, and impair quality of life. Deferasirox (DFX) and deferoxamine (DFO) are among the most commo...

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Detalhes bibliográficos
Publicado no:Drug Des Devel Ther
Main Authors: Wu, Dijiong, Wen, Xiaowen, Liu, Wenbin, Hu, Huijin, Ye, Baodong, Zhou, Yuhong
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5937503/
https://ncbi.nlm.nih.gov/pubmed/29760547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S161086
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