Ku DNA End-Binding Activity Promotes Repair Fidelity and Influences End-Processing During Nonhomologous End-Joining in Saccharomyces cerevisiae

The Ku heterodimer acts centrally in nonhomologous end-joining (NHEJ) of DNA double-strand breaks (DSB). Saccharomyces cerevisiae Ku, like mammalian Ku, binds and recruits NHEJ factors to DSB ends. Consequently, NHEJ is virtually absent in yeast Ku null (yku70∆ or yku80∆) strains. Previously, we une...

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Detalhes bibliográficos
Publicado no:Genetics
Main Authors: Emerson, Charlene H., Lopez, Christopher R., Ribes-Zamora, Albert, Polleys, Erica J., Williams, Christopher L., Yeo, Lythou, Zaneveld, Jacques E., Chen, Rui, Bertuch, Alison A.
Formato: Artigo
Idioma:Inglês
Publicado em: Genetics Society of America 2018
Assuntos:
Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5937190/
https://ncbi.nlm.nih.gov/pubmed/29500182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.117.300672
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