Loading...

Decarboxylative Annulation of α-Amino Acids with β-Ketoaldehydes

Indolizidine and quinolizidine derivatives are readily assembled from L-proline or (±)-pipecolic acid and β-ketoaldehydes via a decarboxylative annulation process. These reactions are promoted by acetic acid and involve azomethine ylides as reactive intermediates.

Saved in:
Bibliographic Details
Published in:Org Lett
Main Authors: Paul, Anirudra, Thimmegowda, N. R., Cruz, Thiago Galani, Seidel, Daniel
Format: Artigo
Language:Inglês
Published: 2018
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5937137/
https://ncbi.nlm.nih.gov/pubmed/29328663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.orglett.7b03721
Tags: Add Tag
No Tags, Be the first to tag this record!