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Cathepsin-Mediated Cleavage of Peptides from Peptide Amphiphiles Leads to Enhanced Intracellular Peptide Accumulation

Peptides synthesized in the likeness of their native interaction domain(s) are natural choices to target protein–protein interactions (PPIs) due to their fidelity of orthostatic contact points between binding partners. Despite therapeutic promise, intracellular delivery of biofunctional peptides at...

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Publicat a:Bioconjug Chem
Autors principals: Acar, Handan, Samaeekia, Ravand, Schnorenberg, Mathew R., Sasmal, Dibyendu K, Huang, Jun, Tirrell, Matthew V., LaBelle, James L.
Format: Artigo
Idioma:Inglês
Publicat: 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5937119/
https://ncbi.nlm.nih.gov/pubmed/28771332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.bioconjchem.7b00364
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