Time-resolved transcriptome and proteome landscape of human regulatory T cell (Treg) differentiation reveals novel regulators of FOXP3

BACKGROUND: Regulatory T cells (Tregs) expressing the transcription factor FOXP3 are crucial mediators of self-tolerance, preventing autoimmune diseases but possibly hampering tumor rejection. Clinical manipulation of Tregs is of great interest, and first-in-man trials of Treg transfer have achieved...

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Veröffentlicht in:BMC Biol
Hauptverfasser: Schmidt, Angelika, Marabita, Francesco, Kiani, Narsis A., Gross, Catharina C., Johansson, Henrik J., Éliás, Szabolcs, Rautio, Sini, Eriksson, Matilda, Fernandes, Sunjay Jude, Silberberg, Gilad, Ullah, Ubaid, Bhatia, Urvashi, Lähdesmäki, Harri, Lehtiö, Janne, Gomez-Cabrero, David, Wiendl, Heinz, Lahesmaa, Riitta, Tegnér, Jesper
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2018
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5937035/
https://ncbi.nlm.nih.gov/pubmed/29730990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12915-018-0518-3
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