Analyzing Th17 cell differentiation dynamics using a novel integrative modeling framework for time-course RNA sequencing data

BACKGROUND: The differentiation of naive CD 4(+) helper T (Th) cells into effector Th17 cells is steered by extracellular cytokines that activate and control the lineage specific transcriptional program. While the inducing cytokine signals and core transcription factors driving the differentiation t...

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Detalhes bibliográficos
Publicado no:BMC Syst Biol
Main Authors: Intosalmi, Jukka, Ahlfors, Helena, Rautio, Sini, Mannerstöm, Henrik, Chen, Zhi Jane, Lahesmaa, Riitta, Stockinger, Brigitta, Lähdesmäki, Harri
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4650136/
https://ncbi.nlm.nih.gov/pubmed/26578352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12918-015-0223-6
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