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The HUS box is required for allosteric regulation of the Sec7 Arf-GEF

The Golgi complex is the central membrane and protein-sorting station in eukaryotic cells. Activation of Arf (ADP-ribosylation factor) GTPases is essential for vesicle formation via recruitment of cargo adaptors and coat proteins necessary for Golgi trafficking. Arf activation is spatially and tempo...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Autores principales: Halaby, Steve L., Fromme, J. Christopher
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2018
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5936818/
https://ncbi.nlm.nih.gov/pubmed/29514977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.001318
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