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Biased Signalling: From Simple Switches to Allosteric Microprocessors

G protein-coupled receptors (GPCRs) are the largest class of receptors in the human genome and one of the most common drug targets. It is now well-established that GPCRs can signal through multiple transducers, including heterotrimeric G proteins, G protein receptor kinases and βarrestins. While the...

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Détails bibliographiques
Publié dans:Nat Rev Drug Discov
Auteurs principaux: Smith, Jeffrey S, Lefkowitz, Robert J, Rajagopal, Sudarshan
Format: Artigo
Langue:Inglês
Publié: 2018
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5936084/
https://ncbi.nlm.nih.gov/pubmed/29302067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrd.2017.229
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