Cyclizing-berberine A35 induces G2/M arrest and apoptosis by activating YAP phosphorylation (Ser127)

BACKGROUND: A35 is a novel synthetic cyclizing-berberine recently patented as an antitumor compound. Based on its dual targeting topoisomerase (top) activity, A35 might overcome the resistance of single-target top inhibitors and has no cardiac toxicity for not targeting top2β. In this study we furth...

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Bibliographic Details
Published in:J Exp Clin Cancer Res
Main Authors: Zhao, Wuli, Liu, Hong, Wang, Junxia, Wang, Mengyan, Shao, Rongguang
Format: Artigo
Language:Inglês
Published: BioMed Central 2018
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5935996/
https://ncbi.nlm.nih.gov/pubmed/29728107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-018-0759-6
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