Inhibition of the PI3K but not the MEK/ERK pathway sensitizes human glioma cells to alkylating drugs

BACKGROUND: Intrinsic chemoresistance of glioblastoma (GBM) is frequently owed to activation of the PI3K and MEK/ERK pathways. These signaling cascades are tightly interconnected however the quantitative contribution of both to intrinsic resistance is still not clear. Here, we aimed at determining t...

Полное описание

Сохранить в:
Библиографические подробности
Опубликовано в: :Cancer Cell Int
Главные авторы: Haas, Bodo, Klinger, Veronika, Keksel, Christina, Bonigut, Verena, Kiefer, Daniela, Caspers, Julia, Walther, Julia, Wos-Maganga, Maria, Weickhardt, Sandra, Röhn, Gabriele, Timmer, Marco, Frötschl, Roland, Eckstein, Niels
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2018
Предметы:
Primary Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5935937/
https://ncbi.nlm.nih.gov/pubmed/29755294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12935-018-0565-4
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы