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Inhibition of the PI3K but not the MEK/ERK pathway sensitizes human glioma cells to alkylating drugs
BACKGROUND: Intrinsic chemoresistance of glioblastoma (GBM) is frequently owed to activation of the PI3K and MEK/ERK pathways. These signaling cascades are tightly interconnected however the quantitative contribution of both to intrinsic resistance is still not clear. Here, we aimed at determining t...
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| Опубликовано в: : | Cancer Cell Int |
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| Главные авторы: | , , , , , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
BioMed Central
2018
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5935937/ https://ncbi.nlm.nih.gov/pubmed/29755294 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12935-018-0565-4 |
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