Chemically triggered drug release from an antibody-drug conjugate leads to potent antitumour activity in mice

Current antibody-drug conjugates (ADCs) target internalising receptors on cancer cells leading to intracellular drug release. Typically, only a subset of patients with solid tumours has sufficient expression of such a receptor, while there are suitable non-internalising receptors and stroma targets....

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Bibliographic Details
Published in:Nat Commun
Main Authors: Rossin, Raffaella, Versteegen, Ron M., Wu, Jeremy, Khasanov, Alisher, Wessels, Hans J., Steenbergen, Erik J., ten Hoeve, Wolter, Janssen, Henk M., van Onzen, Arthur H. A. M., Hudson, Peter J., Robillard, Marc S.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5935733/
https://ncbi.nlm.nih.gov/pubmed/29728559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03880-y
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