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Active nuclear import and passive nuclear export are the primary determinants of TDP-43 localization
ALS (Amyotrophic Lateral Sclerosis) is a neurodegenerative disease characterized by the redistribution of the RNA binding protein TDP-43 in affected neurons: from predominantly nuclear to aggregated in the cytosol. However, the determinants of TDP-43 localization and the cellular insults that promot...
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| Опубликовано в: : | Sci Rep |
|---|---|
| Главные авторы: | , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Nature Publishing Group UK
2018
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5935693/ https://ncbi.nlm.nih.gov/pubmed/29728608 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-25008-4 |
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