GADD45β loss ablates innate immunosuppression in cancer

T cell exclusion from the tumour microenvironment (TME) is a major barrier to overcoming immune escape. Here we identify a myeloid-intrinsic mechanism governed by the NF-κB effector molecule GADD45β that restricts tumour-associated inflammation and T cell trafficking into tumours. In various models...

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Vydáno v:Cancer Res
Hlavní autoři: Verzella, Daniela, Bennett, Jason, Fischietti, Mariafausta, Thotakura, Anil K., Recordati, Camilla, Pasqualini, Fabio, Capece, Daria, Vecchiotti, Davide, D’Andrea, Daniel, Di Francesco, Barbara, De Maglie, Marcella, Begalli, Federica, Tornatore, Laura, Papa, Salvatore, Lawrence, Toby, Forbes, Stuart J., Sica, Antonio, Alesse, Edoardo, Zazzeroni, Francesca, Franzoso, Guido
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5935595/
https://ncbi.nlm.nih.gov/pubmed/29279355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-17-1833
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