GADD45β loss ablates innate immunosuppression in cancer

T cell exclusion from the tumour microenvironment (TME) is a major barrier to overcoming immune escape. Here we identify a myeloid-intrinsic mechanism governed by the NF-κB effector molecule GADD45β that restricts tumour-associated inflammation and T cell trafficking into tumours. In various models...

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Bibliografske podrobnosti
izdano v:Cancer Res
Main Authors: Verzella, Daniela, Bennett, Jason, Fischietti, Mariafausta, Thotakura, Anil K., Recordati, Camilla, Pasqualini, Fabio, Capece, Daria, Vecchiotti, Davide, D’Andrea, Daniel, Di Francesco, Barbara, De Maglie, Marcella, Begalli, Federica, Tornatore, Laura, Papa, Salvatore, Lawrence, Toby, Forbes, Stuart J., Sica, Antonio, Alesse, Edoardo, Zazzeroni, Francesca, Franzoso, Guido
Format: Artigo
Jezik:Inglês
Izdano: 2017
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5935595/
https://ncbi.nlm.nih.gov/pubmed/29279355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-17-1833
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