GADD45β loss ablates innate immunosuppression in cancer

T cell exclusion from the tumour microenvironment (TME) is a major barrier to overcoming immune escape. Here we identify a myeloid-intrinsic mechanism governed by the NF-κB effector molecule GADD45β that restricts tumour-associated inflammation and T cell trafficking into tumours. In various models...

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Publicado en:Cancer Res
Main Authors: Verzella, Daniela, Bennett, Jason, Fischietti, Mariafausta, Thotakura, Anil K., Recordati, Camilla, Pasqualini, Fabio, Capece, Daria, Vecchiotti, Davide, D’Andrea, Daniel, Di Francesco, Barbara, De Maglie, Marcella, Begalli, Federica, Tornatore, Laura, Papa, Salvatore, Lawrence, Toby, Forbes, Stuart J., Sica, Antonio, Alesse, Edoardo, Zazzeroni, Francesca, Franzoso, Guido
Formato: Artigo
Idioma:Inglês
Publicado: 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5935595/
https://ncbi.nlm.nih.gov/pubmed/29279355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-17-1833
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