A huntingtin knock-in pig model recapitulates features of selective neurodegeneration in Huntington’s disease

Huntington’s disease (HD) is characterized by the preferential loss of the medium spiny neurons in the striatum. Using CRISPR-Cas9 and somatic nuclear transfer technology, we established a knock-in (KI) pig model of HD that endogenously expresses full-length mutant huntingtin (HTT). By breeding this...

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Podrobná bibliografie
Vydáno v:Cell
Hlavní autoři: Yan, Sen, Tu, Zhuchi, Liu, Zhaoming, Fan, Nana, Yang, Huiming, Yang, Su, Yang, Weili, Zhao, Yu, Ouyang, Zhen, Lai, Chengdan, Yang, Huaqiang, Li, Li, Liu, Qishuai, Shi, Hui, Xu, Guangqing, Zhao, Heng, Wei, Hongjiang, Pei, Zhong, Li, Shihua, Lai, Liangxue, Li, Xiao-Jiang
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5935586/
https://ncbi.nlm.nih.gov/pubmed/29606351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.03.005
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