N-terminal Huntingtin Knock-In Mice: Implications of Removing the N-terminal Region of Huntingtin for Therapy

The Huntington’s disease (HD) protein, huntingtin (HTT), is a large protein consisting of 3144 amino acids and has conserved N-terminal sequences that are followed by a polyglutamine (polyQ) repeat. Loss of Htt is known to cause embryonic lethality in mice, whereas polyQ expansion leads to adult neu...

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Enregistré dans:
Détails bibliographiques
Publié dans:PLoS Genet
Auteurs principaux: Liu, Xudong, Wang, Chuan-En, Hong, Yan, Zhao, Ting, Wang, Guohao, Gaertig, Marta A., Sun, Miao, Li, Shihua, Li, Xiao-Jiang
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2016
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4874551/
https://ncbi.nlm.nih.gov/pubmed/27203582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006083
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