A huntingtin knock-in pig model recapitulates features of selective neurodegeneration in Huntington’s disease

Huntington’s disease (HD) is characterized by the preferential loss of the medium spiny neurons in the striatum. Using CRISPR-Cas9 and somatic nuclear transfer technology, we established a knock-in (KI) pig model of HD that endogenously expresses full-length mutant huntingtin (HTT). By breeding this...

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Dettagli Bibliografici
Pubblicato in:Cell
Autori principali: Yan, Sen, Tu, Zhuchi, Liu, Zhaoming, Fan, Nana, Yang, Huiming, Yang, Su, Yang, Weili, Zhao, Yu, Ouyang, Zhen, Lai, Chengdan, Yang, Huaqiang, Li, Li, Liu, Qishuai, Shi, Hui, Xu, Guangqing, Zhao, Heng, Wei, Hongjiang, Pei, Zhong, Li, Shihua, Lai, Liangxue, Li, Xiao-Jiang
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5935586/
https://ncbi.nlm.nih.gov/pubmed/29606351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.03.005
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