Inactivation of cancer-associated-fibroblasts (CAF) disrupts oncogenic signaling in pancreatic cancer cells and promotes its regression

Resident fibroblasts that contact tumor epithelial cells (TEC) can become irreversibly activated as cancer-associated-fibroblasts (CAF) which stimulate oncogenic signaling in TEC. In this study, we evaluated the crosstalk between CAF and TEC isolated from tumors generated in a mouse model of KRAS/mu...

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Udgivet i:Cancer Res
Main Authors: Dauer, Patricia, Zhao, Xianda, Gupta, Vineet K, Sharma, Nikita, Kesh, Kousik, Gnamlin, Prisca, Dudeja, Vikas, Vickers, Selwyn M, Banerjee, Sulagna, Saluja, Ashok
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5935584/
https://ncbi.nlm.nih.gov/pubmed/29259015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-17-2320
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