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Novel Synthetic bisindolylmaleimide alkaloids inhibit STAT3 activation by binding to the SH2 domain and suppress breast xenograft tumor growth

Signal transducer and activator of transcription 3 (STAT3) is constitutively activated in malignant tumors and plays important roles in multiple aspects of cancer aggressiveness. Thus, targeting STAT3 promises to be an attractive strategy for treatment of advanced metastatic tumors. Bisindolylmaleim...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Li, Xia, Ma, Hongguang, Li, Lin, Chen, Yifan, Sun, Xiao, Dong, Zizheng, Liu, Jing-Yuan, Zhu, Weiming, Zhang, Jian-Ting
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5934316/
https://ncbi.nlm.nih.gov/pubmed/29456240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-017-0076-0
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