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Cardioprotective effects of dietary rapamycin on adult female C57BLKS/J-Lepr(db) mice

Rapamycin (RAPA), an inhibitor of mTORC signaling, has been shown to extend life span in mice and other organisms. Recently, animal and human studies have suggested that inhibition of mTORC signaling can alleviate or prevent the development of cardiomyopathy. In view of this, we used a murine model...

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Bibliographische Detailangaben
Veröffentlicht in:Ann N Y Acad Sci
Hauptverfasser: Reifsnyder, Peter C., Ryzhov, Sergey, Flurkey, Kevin, Anunciado-Koza, Rea P., Mills, Ian, Harrison, David E., Koza, Robert A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5934313/
https://ncbi.nlm.nih.gov/pubmed/29377150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/nyas.13557
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