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Cardioprotective effects of dietary rapamycin on adult female C57BLKS/J-Lepr(db) mice

Rapamycin (RAPA), an inhibitor of mTORC signaling, has been shown to extend life span in mice and other organisms. Recently, animal and human studies have suggested that inhibition of mTORC signaling can alleviate or prevent the development of cardiomyopathy. In view of this, we used a murine model...

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Detalhes bibliográficos
Publicado no:Ann N Y Acad Sci
Main Authors: Reifsnyder, Peter C., Ryzhov, Sergey, Flurkey, Kevin, Anunciado-Koza, Rea P., Mills, Ian, Harrison, David E., Koza, Robert A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5934313/
https://ncbi.nlm.nih.gov/pubmed/29377150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/nyas.13557
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