Metformin Suppresses Diethylnitrosamine-Induced Liver Tumorigenesis in Obese and Diabetic C57BL/KsJ-+Lepr(db)/+Lepr(db) Mice

Obesity and related metabolic disorders, such as diabetes mellitus, raise the risk of liver carcinogenesis. Metformin, which is widely used in the treatment of diabetes, ameliorates insulin sensitivity. Metformin is also thought to have antineoplastic activities and to reduce cancer risk. The presen...

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Bibliografiske detaljer
Udgivet i:PLoS One
Main Authors: Ohno, Tomohiko, Shimizu, Masahito, Shirakami, Yohei, Baba, Atsushi, Kochi, Takahiro, Kubota, Masaya, Tsurumi, Hisashi, Tanaka, Takuji, Moriwaki, Hisataka
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4399835/
https://ncbi.nlm.nih.gov/pubmed/25879666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0124081
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