PgaB orthologues contain a glycoside hydrolase domain that cleaves deacetylated poly-β(1,6)-N-acetylglucosamine and can disrupt bacterial biofilms

Poly-β(1,6)-N-acetyl-D-glucosamine (PNAG) is a major biofilm component of many pathogenic bacteria. The production, modification, and export of PNAG in Escherichia coli and Bordetella species require the protein products encoded by the pgaABCD operon. PgaB is a two-domain periplasmic protein that co...

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Veröffentlicht in:PLoS Pathog
Hauptverfasser: Little, Dustin J., Pfoh, Roland, Le Mauff, François, Bamford, Natalie C., Notte, Christina, Baker, Perrin, Guragain, Manita, Robinson, Howard, Pier, Gerald B., Nitz, Mark, Deora, Rajendar, Sheppard, Donald C., Howell, P. Lynne
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2018
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5933820/
https://ncbi.nlm.nih.gov/pubmed/29684093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006998
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