The KAT5-Acetyl-Histone4-Brd4 axis silences HIV-1 transcription and promotes viral latency

The bromodomain protein Brd4 promotes HIV-1 latency by competitively inhibiting P-TEFb-mediated transcription induced by the virus-encoded Tat protein. Brd4 is recruited to the HIV LTR by interactions with acetyl-histones3 (AcH3) and AcH4. However, the precise modification pattern that it reads and...

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Udgivet i:PLoS Pathog
Main Authors: Li, Zichong, Mbonye, Uri, Feng, Zeming, Wang, Xiaohui, Gao, Xiang, Karn, Jonathan, Zhou, Qiang
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5933813/
https://ncbi.nlm.nih.gov/pubmed/29684085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1007012
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