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The KAT5-Acetyl-Histone4-Brd4 axis silences HIV-1 transcription and promotes viral latency
The bromodomain protein Brd4 promotes HIV-1 latency by competitively inhibiting P-TEFb-mediated transcription induced by the virus-encoded Tat protein. Brd4 is recruited to the HIV LTR by interactions with acetyl-histones3 (AcH3) and AcH4. However, the precise modification pattern that it reads and...
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| Publicado en: | PLoS Pathog |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Public Library of Science
2018
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5933813/ https://ncbi.nlm.nih.gov/pubmed/29684085 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1007012 |
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